Tumor necrosis factor-α blockade treatment decreased CD154 (CD40-ligand) expression in rheumatoid arthritis.
Chien-Hsueh TungMing-Chi LuNing-Sheng LaiShu-Fen WuPublished in: PloS one (2017)
TNF-α blockade treatment significantly decreased the CD154 expression on CD4+ T cells, disease activity and anti-CCP antibody simultaneously in RA patients. However TNF-α blockade did not impair T cell capacity to express CD154 after stimulation. These results suggest that decreased CD154 expression after TNF-α blockade may be due to decreased RA disease activity but not direct inhibition of CD154 responsiveness of T cells.
Keyphrases
- rheumatoid arthritis
- disease activity
- ankylosing spondylitis
- rheumatoid arthritis patients
- poor prognosis
- systemic lupus erythematosus
- juvenile idiopathic arthritis
- interstitial lung disease
- binding protein
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- long non coding rna
- prognostic factors
- combination therapy