IL-23 skin and joint profiling in psoriatic arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors.
Alessandra NervianiMarie-Astrid BoutetWang Sin Gina TanKatriona GoldmannNirupam PurkayasthaTamas Ajtos LajtosRebecca HandsMyles J LewisStephen KellyCostantino PitzalisPublished in: Annals of the rheumatic diseases (2020)
PsA synovial tissue shows a heterogeneous IL-23 axis profile when compared with matched skin. Synovial molecular pathology may help to identify among clinically indistinguishable patients those with a greater probability of responding to IL-23 inhibitors.