Functional roles of microRNAs in vasculogenic mimicry and resistance to therapy in human cancers: an update.
Alejandra Paola García-HernándezGricelda Sánchez-SánchezAngeles Carlos-ReyesCesar López-CamarilloPublished in: Expert review of clinical immunology (2024)
The miRNAs are regulators of protein-encoding genes involved in VM; however, their specific expression signatures with clinical value in large cohorts of patients have not been established yet. We considered that genomic profiling of miRNAs could be useful to define some hallmarks of tumors such as stemness, drug resistance, and VM in cancer patients. However, additional studies are needed to establish the relevant role of miRNAs as effective therapeutic targets in tumors that have developed VM.
Keyphrases
- end stage renal disease
- endothelial cells
- stem cells
- newly diagnosed
- ejection fraction
- chronic kidney disease
- poor prognosis
- peritoneal dialysis
- binding protein
- prognostic factors
- epithelial mesenchymal transition
- transcription factor
- gene expression
- genome wide
- protein protein
- bone marrow
- case control
- pluripotent stem cells