A Review of Macrophage MicroRNAs' Role in Human Asthma.
Gavriela Maria FeketeaCorina I BocsanCristian PopescuMihaela GamanLuminita A StanciuMihnea T ZdrengheaPublished in: Cells (2019)
There is an imbalance in asthma between classically activated macrophages (M1 cells) and alternatively activated macrophages (M2 cells) in favor of the latter. MicroRNAs (miRNAs) play a critical role in regulating macrophage proliferation and differentiation and control the balance of M1 and M2 macrophage polarization, thereby controlling immune responses. Here we review the current published data concerning miRNAs with known correlation to a specific human macrophage phenotype and polarization, and their association with adult asthma. MiRNA-targeted therapy is still in the initial stages, but clinical trials are under recruitment or currently running for some miRNAs in other diseases. Regulating miRNA expression via their upregulation or downregulation could show potential as a novel therapy for improving treatment efficacy in asthma.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- induced apoptosis
- endothelial cells
- allergic rhinitis
- signaling pathway
- clinical trial
- immune response
- poor prognosis
- adipose tissue
- cell cycle arrest
- cell proliferation
- pluripotent stem cells
- induced pluripotent stem cells
- endoplasmic reticulum stress
- cystic fibrosis
- long non coding rna
- electronic health record
- binding protein
- young adults
- smoking cessation
- phase ii
- placebo controlled