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The Future of Medicinal Chemistry, PROTAC, and Undruggable Drug Targets.

Antti Poso
Published in: Journal of medicinal chemistry (2021)
WRD5 is a promising target for anticancer drug discovery. In addition, it plays a vital role in epigenetic regulation. Since biological inactivation of WRD5 is difficult to reach via classical approach, PROTACs (Proteolysis Targeting Chimeras) are offering a new option. In a study, published in this journal, new WRD5 targeting PROTACS are introduced. These new compounds, which are also active in cells, make it possible to evaluate the value of WRD5 as a drug target.
Keyphrases
  • drug discovery
  • induced apoptosis
  • cancer therapy
  • cell cycle arrest
  • adverse drug
  • oxidative stress
  • current status
  • systematic review
  • randomized controlled trial
  • cell death
  • signaling pathway