Single-cell Analysis of Subcutaneous Fat Reveals Pro-fibrotic Cells that Correlate with Visceral Adiposity in HIV.
Samuel S BailinCurtis L GabrielRama D GangulaLaToya HannahSangeeta NairJohn Jeffrey CarrJames G TerryHeidi J SilverJoshua D SimmonsMona MashayekhiSpyros A KalamsSimon MallalJonathan A KropskiCelestine N WanjallaJohn R KoethePublished in: The Journal of clinical endocrinology and metabolism (2024)
In PWH, greater VAT volume is associated with higher proportion of SAT IMs and fibroblasts, and a SAT ECM and inflammatory transcriptome, which is similar to findings in HIV-negative persons with obesity. These data identify SAT cell-type specific changes associated with VAT volume in PWH that could underlie the high rates of cardiometabolic diseases in PWH, though additional longitudinal studies are needed to define directionality and mechanisms.
Keyphrases
- single cell
- insulin resistance
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- rna seq
- hepatitis c virus
- hiv aids
- adipose tissue
- induced apoptosis
- men who have sex with men
- metabolic syndrome
- weight gain
- extracellular matrix
- type diabetes
- cell cycle arrest
- weight loss
- systemic sclerosis
- oxidative stress
- electronic health record
- south africa
- high fat diet induced
- idiopathic pulmonary fibrosis
- signaling pathway
- cross sectional
- genome wide
- big data
- skeletal muscle
- cell death
- endoplasmic reticulum stress
- anti inflammatory
- fatty acid
- cell proliferation
- deep learning
- body mass index
- case control
- machine learning
- artificial intelligence