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A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation.

Michael RadeSebastian BöhlenVanessa NeuhausDennis LöfflerConny BlumertMaximilian MerzUlrike KöhlSusann DehmelKatherina SewaldKristin Reiche
Published in: Genome biology (2023)
This study is the first to describe temporally resolved gene expression patterns across T-cell populations. These biomarker signatures are a valuable source, e.g., monitoring transcriptional changes during T-cell activation with a reasonable number of genes, annotating T-cell states in single-cell transcriptome studies, or assessing dysregulated functions of human T-cell immunity.
Keyphrases
  • gene expression
  • endothelial cells
  • single cell
  • dna methylation
  • systematic review
  • genome wide
  • rna seq
  • induced pluripotent stem cells
  • pluripotent stem cells
  • case control
  • randomized controlled trial
  • oxidative stress