Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation.

Rou-Ling ChoChien-Chung YangHui-Ching TsengLi-Der HsiaoChih-Chung LinChuen-Mao Yang

Published in: British journal of pharmacology (2018)

Rosiglitazone induces HO-1 expression via either NOX/ROS/c-Src/Pyk2/Akt-dependent Nrf2 activation or PPARγ in HPAEpiCs and suppresses LPS-mediated inflammatory responses, suggesting that PPARγ agonists may be useful for protection against pulmonary inflammation.

Keyphrases

oxidative stress
dna damage
reactive oxygen species
anti inflammatory
insulin resistance
signaling pathway
inflammatory response
cell death
poor prognosis
pulmonary hypertension
fatty acid
cell proliferation
tyrosine kinase
metabolic syndrome
pi k akt
type diabetes
adipose tissue