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Expression pattern of perilipins in human brain during aging and in Alzheimer's disease.

Maria ConteValentina MediciDavide MalagoliAntonio ChiarielloAlice CirrincioneAnnalisa DavinMaia ChikhladzeFrancesco VasuriGiuseppe LegnameIsidro FerrerSilvia VanniGabriella MarconTino Emanuele PoloniAntonio GuaitaClaudio FranceschiStefano Salvioli
Published in: Neuropathology and applied neurobiology (2021)
Perilipins are expressed in human brain but only Plin2 appears to be modulated with age and neurodegeneration and linked to an inflammatory state. We propose that the accumulation of lipid droplets decorated with Plin2 occurs during brain aging and that this accumulation may be an early marker and initial step of inflammation and neurodegeneration.
Keyphrases
  • oxidative stress
  • poor prognosis
  • resting state
  • white matter
  • cognitive decline
  • binding protein
  • fatty acid
  • functional connectivity
  • long non coding rna