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The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes.

Tina HörbeltChristopher TackeMariya MarkovaDaniella Herzfeld de WizaFrederique Van de VeldeMarlies BekaertYves Van NieuwenhoveSilke HornemannMaria RödigerNicole SeebeckElisabeth FriedlWenke JonasG Hege ThoresenOliver KussAnke RosenthalVolker LangeAndreas F H PfeifferAnnette SchürmannBruno LapauwNatalia RudovichOlga PivovarovaD Margriet Ouwens
Published in: Diabetologia (2018)
Circulating WISP1 levels and WISP1 expression in VAT are increased in obesity independent of glycaemic status. Furthermore, WISP1 impaired insulin signalling in muscle and liver cells.
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