The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes.
Tina HörbeltChristopher TackeMariya MarkovaDaniella Herzfeld de WizaFrederique Van de VeldeMarlies BekaertYves Van NieuwenhoveSilke HornemannMaria RödigerNicole SeebeckElisabeth FriedlWenke JonasG Hege ThoresenOliver KussAnke RosenthalVolker LangeAndreas F H PfeifferAnnette SchürmannBruno LapauwNatalia RudovichOlga PivovarovaD Margriet OuwensPublished in: Diabetologia (2018)
Circulating WISP1 levels and WISP1 expression in VAT are increased in obesity independent of glycaemic status. Furthermore, WISP1 impaired insulin signalling in muscle and liver cells.
Keyphrases
- type diabetes
- insulin resistance
- glycemic control
- metabolic syndrome
- skeletal muscle
- induced apoptosis
- endothelial cells
- high fat diet induced
- poor prognosis
- high fat diet
- adipose tissue
- cell cycle arrest
- induced pluripotent stem cells
- weight loss
- signaling pathway
- long non coding rna
- cell proliferation
- pluripotent stem cells
- binding protein
- oxidative stress
- liver injury