Chromatin Accessibility Identifies Regulatory Elements Predictive of Gene Expression and Disease Outcome in Multiple Myeloma.
Benjamin G BarwickVilas A GuptaShannon M MatulisJonathan C PattonDoris R PowellYanyan GuDavid L JayeKaren N ConneelyYin C LinCraig C HofmeisterAjay K NookaJonathan J KeatsSagar LonialPaula M VertinoLawrence H BoisePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
These data demonstrate the feasibility of using biobanked specimens for retrospective studies of the myeloma epigenome and illustrate the unique enhancer landscapes of myeloma subtypes that are coupled to gene expression and disease progression.