Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p.

Yu-Zhong YuDao-Jun LvChong WangXian-Lu SongTao XieTao WangZhi-Min LiJia-Ding GuoDu-Jiang FuKang-Jin LiDing-Lan WuFranky Leung ChanNing-Han FengZhe-Sheng Chen Shan-Chao Zhao

Published in: Molecular cancer (2022)

Upregulation of hsa_circ_0003258 drives tumor progression through both hsa_circ_0003258/miR-653-5p/ARHGAP5 axis and hsa_circ_0003258/IGF2BP3 /HDAC4 axis. Hsa_circ_0003258 may act as a promising biomarker for metastasis of PCa and an attractive target for PCa intervention.

Keyphrases

prostate cancer
poor prognosis
randomized controlled trial
pi k akt
radical prostatectomy
cell proliferation
signaling pathway
binding protein
histone deacetylase