Reversine enhances the conversion of dedifferentiated fat cells into mature cardiomyocytes.

Budi Baktijasa DharmadjatiDjanggan SargowoAulanni'am Aulanni'am Budi Susetio PikirYudi Her OktavionoOryza SativaKandita ArjaniRicardo Adrian Nugraha

Published in: F1000Research (2024)

Reversine could increase the expression of Flk-1, but it was unable to stimulate the expression of Oct4 and brachyury related to cell stemness. An optimal concentration of 10 nM reversine may have the greatest effect on enhancing the differentiation of DFAT cells into mature cardiomyocytes, as indicated by higher cTnT expression between cells.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
stem cells
binding protein
endoplasmic reticulum stress
cell death
signaling pathway
photodynamic therapy
cell therapy
endothelial cells
fatty acid
pi k akt
optic nerve