Preclinical pharmacokinetics and tolerability of a novel meglumine-based parenteral solution of topiramate and topiramate combinations for treatment of status epilepticus.

Chris RundfeldtPavel KleinDetlev BoisonAlexander RotenbergRaimondo D'AmbrosioCliff EastmanBenton PurnellMadhuvika MuruganHoward P GoodkinWolfgang Löscher

Published in: Epilepsia (2023)

In conclusion, the novel meglumine-based solution of TPM presented here may be well suited for clinical development.

Keyphrases

combination therapy
open label
randomized controlled trial
clinical trial
solid state
mesenchymal stem cells