Hippocampal neuroprotection mediated by secretome of human mesenchymal stem cells against experimental stroke.
Afsaneh Asgari TaeiLeila DargahiPariya KhodabakhshMehdi KadivarMaryam FarahmandfarPublished in: CNS neuroscience & therapeutics (2022)
Our results suggest that hESC-MSC-CM could promote neurogenesis and protect brain tissue from ischemic injury, partly mediated by induction of angiogenesis and neurotrophic factors and inhibition of inflammatory and apoptotic factors expression.
Keyphrases
- cerebral ischemia
- endothelial cells
- subarachnoid hemorrhage
- mesenchymal stem cells
- blood brain barrier
- brain injury
- poor prognosis
- cell death
- umbilical cord
- oxidative stress
- vascular endothelial growth factor
- bone marrow
- stem cells
- white matter
- resting state
- pluripotent stem cells
- functional connectivity
- long non coding rna