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Long-term effects of ipragliflozin and pioglitazone on metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes: 5 year observational follow-up of a randomized, 24 week, active-controlled trial: Effect of ipragliflozin in MASLD.

Daisuke ItoSatoshi ShimizuAkifumi HaisaShinnosuke YanagisawaKazuyuki InoueDaigo SaitoTakashi SumitaMorifumi YanagisawaYoshihito UchidaKouichi InukaiAkira Shimada
Published in: Journal of diabetes investigation (2024)
Ipragliflozin and pioglitazone improved MASLD and glycemic parameters over 5 years. In the ipragliflozin group, significant reductions in body weight and visceral fat mass persisted for 5 years.
Keyphrases
  • body weight
  • adipose tissue
  • oxidative stress
  • insulin resistance
  • open label
  • randomized controlled trial
  • clinical trial
  • metabolic syndrome
  • fatty acid
  • double blind
  • skeletal muscle
  • glycemic control