Synthesis of Unnatural Amino Acids via Ni/Ag Electrocatalytic Cross-Coupling.
Gabriele LaudadioPhilipp NeigenfindRajesh CheboluVanna D BlasczakShambabu Joseph MaddiralaMaximilian D PalkowitzPhilippe N BolducMichael C NicastriRavi Kumar PuthukanooriBheema Rao ParaselliPhil S BaranPublished in: Organic letters (2024)
A simple protocol is outlined herein for rapid access to enantiopure unnatural amino acids (UAAs) from trivial glutamate and aspartate precursors. The method relies on Ag/Ni-electrocatalytic decarboxylative coupling and can be rapidly conducted in parallel (24 reactions at a time) to ascertain coupling viability followed by scale-up for the generation of useful quantities of UAAs for exploratory studies.