Effects of Etanercept on Experimental Osteoarthritis in Rats: Role of Histone Deacetylases.

Zhi-Hong WenChi-Chieh TangYen-You LinZhi-Kang YaoShih-Peng Hsiehnull Gar-Hwa-LaiWu-Fu ChenYen-Hsuan Jean

Published in: Cartilage (2024)

Our study demonstrated that etanercept therapy (1) attenuated the development of OA and synovitis in rats, (2) reduced nociception, and (3) regulated chondrocyte metabolism, possibly by inhibiting cell HDAC6 and HDAC7, RUNX2, and MMP13 and increasing HDAC4 expression. Based on new evidence, etanercept may have therapeutic potential in OA.

Keyphrases

rheumatoid arthritis
rheumatoid arthritis patients
ankylosing spondylitis
histone deacetylase
juvenile idiopathic arthritis
knee osteoarthritis
transcription factor
disease activity
poor prognosis
cell therapy
single cell
signaling pathway
stem cells
gene expression
binding protein
mesenchymal stem cells