Mangifera Indica leaf extracts promote hair growth via activation of Wnt signaling pathway in human dermal papilla cells.
Haesoo JungDa-Min JungSang-Soo LeeEun-Mi KimKyungah YoonEun-Mi KimPublished in: Animal cells and systems (2022)
The crosstalk between androgens and Wnt signaling pathways is critical in the hair growth cycle. Therefore, natural products that target these two pathways for the inhibition of hair loss are sought after. In this study, we investigated the effect of water extracts of Mangifera indica leaves (WEML) on hair growth. WEML treatment significantly reduced the expression levels of both dickkopf-1 ( DKK1 ) and type 2 5α-reductase (SRD5A2) involved in Wnt signal suppression activity and dihydrotestosterone (DHT) synthesis, respectively, in human follicle dermal papilla cells (HFDP). In addition, WEML treatment effectively upregulated Wnt target genes and downregulated DKK 1 expression that was increased by DHT treatment. Degranulation analysis in rat basophilic leukemia mast cell line (RBL-2H3) using β-hexosaminidase release assay confirmed that WEML did not exhibit allergenic activity. Furthermore, hair growth was significantly enhanced in in vivo mice model treated with WEML. These results suggest that M. indica leave extract contains bioactive materials that can be used to treat hair loss.
Keyphrases
- signaling pathway
- induced apoptosis
- stem cells
- cell proliferation
- endothelial cells
- poor prognosis
- oxidative stress
- epithelial mesenchymal transition
- gene expression
- cell cycle arrest
- bone marrow
- genome wide
- adipose tissue
- metabolic syndrome
- cell death
- insulin resistance
- high resolution
- replacement therapy
- transcription factor
- induced pluripotent stem cells
- single molecule
- pluripotent stem cells
- smoking cessation
- newly diagnosed