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The effect of alemtuzumab on neurodegeneration in relapsing-remitting multiple sclerosis: A five-year prospective mono-center study.

Sofia SandgrenLenka NovakovaAnna NordinHemin SabirMarkus AxelssonClas MalmeströmHenrik ZetterbergJan Lycke
Published in: Multiple sclerosis and related disorders (2024)
We showed that neurodegeneration continued in RRMS patients under ALZ treatment, but it appeared to be limited to BPF and GM, and more pronounced in patients with disease activity. Our data suggest that patients who respond to ALZ treatment show signs of remyelination. OCT and SyMRI have potential to quantify measures of neurodegeneration that is affected by treatment intervention in RRMS.
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