Ciliated Cells Express a Novel Pattern of Brain-Derived Neurotrophic Factor in Allergic Rhinitis.

Li FangChun-Hao LiQian Zhang Tian-Jiao JiangYuan LiuFeng-Po ShiPeng YuLiang YuAi-Ping ChenTao LiYu-Zhu WanLi Shi

Published in: Journal of inflammation research (2023)

Our study shows for the first time that, the expression and localization of BNDF were observed in the human nasal ciliated epithelial cells of allergic rhinitis, and the expression of level was less than the control group under the persistent state of allergy. BDNF expression in ciliated cells was transient increased after allergen stimulation and decreased to normal level after 24h in mouse model of allergic rhinitis. This might be the possible source of the transient increase of BNDF in serum and NAL fluid.

Keyphrases

allergic rhinitis
poor prognosis
induced apoptosis
mouse model
cell cycle arrest
binding protein
long non coding rna
oxidative stress
endoplasmic reticulum stress
cerebral ischemia
brain injury
stress induced
blood brain barrier
pi k akt
pluripotent stem cells