Serum IFNα2 measured by single-molecule array associates with systemic disease manifestations in Sjögren's syndrome.

Erika HuijserJens GöpfertZana BrkicCornelia G van Helden-MeeuwsenSanne JansenThomas MandlPeter OlssonBenjamin SchrijverMarco W J SchreursPaul L A van DaeleWillem A DikMarjan A Versnel

Published in: Rheumatology (Oxford, England) (2021)

Thus, Simoa serum IFNα2 reflects blood ISG expression in pSS, SLE, and SSc. In light of IFN-targeting treatments, Simoa could potentially be applied for patient stratification or retrospective analysis of historical cohorts.

Keyphrases

single molecule
dendritic cells
immune response
case report
systemic lupus erythematosus
poor prognosis
disease activity
atomic force microscopy
living cells
high resolution
cross sectional
binding protein
fluorescent probe