Metabolic Profile and Metabolite Analyses in Extreme Weight Responders to Gastric Bypass Surgery.
Charlotte M FriesSven-Bastiaan HaangeUlrike E Rolle-KampczykAndreas TillMathis LammertLinda GrasserEvelyn MedawarArne DietrichAnnette HorstmannMartin von BergenWiebke K FenskePublished in: Metabolites (2022)
Heterogenous weight loss response to RYGB surgery separates from patients' metabolic outcome, and is linked to unique serum metabolite signatures post intervention. These findings suggest that the level of adiposity reduction alone is insufficient to assess the metabolic success of RYGB surgery, and that longitudinal metabolite profiling may eventually help us to identify markers that could predict individual adiposity response to surgery and guide patient selection and counseling.
Keyphrases
- minimally invasive
- weight loss
- coronary artery bypass
- roux en y gastric bypass
- gastric bypass
- randomized controlled trial
- surgical site infection
- insulin resistance
- newly diagnosed
- ejection fraction
- type diabetes
- percutaneous coronary intervention
- climate change
- obese patients
- gene expression
- cross sectional
- coronary artery disease
- patient reported outcomes
- smoking cessation
- dna methylation
- human immunodeficiency virus
- acute coronary syndrome
- antiretroviral therapy