Overexpression of Synoviolin and miR-125a-5p, miR-19b-3p in peripheral blood of rheumatoid arthritis patients after treatment with conventional DMARDs and methylprednisolone.
Negin KaramaliZahra MahmoudiSeyed Askar RoghaniShirin AssarMehran PournazariParviz SoufivandAli Gorgin KarajiAlireza RezaiemaneshPublished in: Clinical rheumatology (2023)
The results indicate the ineffectiveness of the csDMARDs in reducing SYVN1 expression. The difference in expression of ncRNAs might be useful markers for monitoring disease activity and determining therapeutic responses in RA patients. Key Points • The expression of NEAT1 is significantly upregulated in RA patients compared to HC subjects. • miR-19b-3p, miR-125a-5p, and SYVN1 are significantly upregulated in RA patients compared to HC subjects. • The expression of miR-19b-3p and miR-125a-5p is significantly increased in RA patients after treatment with DMARDs and methylprednisolone. • NEAT1 is positively correlated with SYVN1.
Keyphrases
- disease activity
- end stage renal disease
- rheumatoid arthritis patients
- rheumatoid arthritis
- newly diagnosed
- chronic kidney disease
- ejection fraction
- poor prognosis
- prognostic factors
- peripheral blood
- peritoneal dialysis
- ankylosing spondylitis
- high dose
- low dose
- patient reported outcomes
- juvenile idiopathic arthritis
- transcription factor
- patient reported