Inhibition of Acyl-CoA Synthetase Long Chain Isozymes Decreases Multiple Myeloma Cell Proliferation and Causes Mitochondrial Dysfunction.

Connor S MurphyVictoria E DeMambroSamaa FadelHeather FairfieldCarlos A GarterPrincess RodriguezYa-Wei QiangCalvin P H VaryMichaela R Reagan

Published in: bioRxiv : the preprint server for biology (2024)

Overall, our data support the hypothesis that suppression of ACSL in human MM cells inhibit their growth and viability, indicating that ACSL proteins may be promising therapeutic targets in treating myeloma progression.

Keyphrases

multiple myeloma
cell proliferation
induced apoptosis
endothelial cells
cell cycle arrest
fatty acid
electronic health record
induced pluripotent stem cells
cell cycle
pi k akt
endoplasmic reticulum stress
pluripotent stem cells
cell death
oxidative stress
newly diagnosed
machine learning
deep learning