Upstream open reading frames regulate translation of cancer-associated transcripts and encode HLA-presented immunogenic tumor antigens.
Annika NeldeLea FlötottoLara JürgensLaura SzymikElvira HubertJens BauerChristoph SchliemannTorsten KesslerGeorg LenzHans-Georg RammenseeJuliane Sarah WalzKlaus WethmarPublished in: Cellular and molecular life sciences : CMLS (2022)
Our data provide direct evidence for the frequent expression of uPeptides in benign and malignant human tissues, suggesting a potentially widespread function of uPeptides in cancer biology. These findings may inspire novel approaches in direct molecular as well as immunotherapeutic targeting of cancer-associated uORFs and uPeptides.
Keyphrases
- endothelial cells
- papillary thyroid
- poor prognosis
- minimally invasive
- gene expression
- electronic health record
- squamous cell
- working memory
- dendritic cells
- induced pluripotent stem cells
- big data
- cancer therapy
- pluripotent stem cells
- squamous cell carcinoma
- binding protein
- long non coding rna
- childhood cancer
- artificial intelligence