Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells.
Maryam FarzanehAva NasrolahiFarhoodeh GhaedrahmatiTariq MasoodiSajad NajafiMohadeseh Sheykhi-SabzehpoushMahrokh Abouali Gale DariKlaudia RadoszkiewiczShahab UddinShirin AzizidoostSeyed Esmaeil KhoshnamPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)
Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.