The Mutually Mediated Chloride Intracellular Channel Protein 1 (CLIC1) Relationship between Malignant Cells and Tumor Blood Vessel Endothelium Exhibits a Significant Impact on Tumor Angiogenesis, Progression, and Metastasis in Clear Cell Renal Cell Carcinoma (ccRCC).
Adela Maria FericianOvidiu Catalin FericianAlexandru NesiuAndrei Alexandru CosmaBorislav Dusan CaplarEugen MelnicAnca Maria CîmpeanPublished in: Cancers (2022)
Co-expression of ccRCC tumor and endothelial cells promotes tumor progression and metastasis and should be investigated further as a potential therapeutic target for ccRCC and other human malignancies.