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Functional impairment of chronic migraine with medication overuse: Secondary analysis from the Medication Overuse Treatment Strategy (MOTS) trial.

Samantha C ShaoJoseph HentzPatti ShankMichael LeonardDavid W DodickTodd J Schwedt
Published in: Headache (2024)
The negative impact of chronic migraine with medication overuse on physical, social, and emotional functioning substantially lessened following initiation or modification of migraine preventive medication. Improved functioning, as measured by the MFIQ, was most strongly associated with reductions in depression scores and headache frequency, highlighting the importance of recognizing and monitoring changes in depressive symptoms, in addition to headache frequency and functional impairment, when evaluating response to preventive medications.
Keyphrases
  • depressive symptoms
  • healthcare
  • adverse drug
  • mental health
  • randomized controlled trial
  • social support
  • emergency department
  • phase iii
  • drug induced
  • phase ii
  • combination therapy
  • open label
  • replacement therapy