The Intestinal Microbiota and Short-Chain Fatty Acids in Association with Advanced Metrics of Glycemia and Adiposity Among Young Adults with Type 1 Diabetes and Overweight or Obesity.
Daria IgudesmanJamie CrandellKaren D CorbinFranklin MuntisDessi P ZaharievaAnna CasuJoan M ThomasCynthia M BulikIan M CarrollBrian W PenceRichard E PratleyMichael R KosorokDavid M MaahsElizabeth J Mayer-DavisPublished in: Current developments in nutrition (2022)
Unexpectedly, fecal propionate was associated with detriment to glycemia, whereas most SCFA-producing intestinal microbes were associated with benefit to adiposity. Future studies should confirm these associations and determine their potential causal linkages in T1D.This study is registered at clinical.trials.gov (NCT03651622; https://clinicaltrials.gov/ct2/show/NCT03651622).
Keyphrases
- weight gain
- insulin resistance
- young adults
- clinical trial
- weight loss
- fatty acid
- metabolic syndrome
- type diabetes
- computed tomography
- body mass index
- adipose tissue
- physical activity
- high fat diet induced
- image quality
- skeletal muscle
- current status
- randomized controlled trial
- dual energy
- climate change
- risk assessment
- phase ii