Neoadjuvant intratumoral influenza vaccine treatment in patients with proficient mismatch repair colorectal cancer leads to increased tumor infiltration of CD8+ T cells and upregulation of PD-L1: a phase 1/2 clinical trial.

Mikail GögenurLukas BalseviciusMustafa BulutNesibe ColakTobias Freyberg JustesenAnne-Marie Kanstrup FiehnMarianne Bøgevang JensenKathrine Høst-RasmussenBritt CappelenShruti GaggarAsma TajikJawad Ahmad ZahidAstrid Louise Bjørn BennedsenTommaso Del Buono D'OndesHans RaskovSusanne Gjørup SækmoseLasse Bremholm HansenAli SalantiSusanne BrixIsmail Gögenur

Published in: Journal for immunotherapy of cancer (2023)

NCT04591379.

Keyphrases

clinical trial
rectal cancer
lymph node
poor prognosis
locally advanced
signaling pathway
cell proliferation
randomized controlled trial
squamous cell carcinoma
phase iii
replacement therapy