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Serum Protein Exposure Activates a Core Regulatory Program Driving Human Proximal Tubule Injury.

Kevin A LidbergSelvaraj MuthusamyMohamed AdilAnish MahadeoJade YangRanita S PatelLu WangTheo K BammlerJonathan ReichelCatherine K YeungJonathan HimmelfarbEdward J KellyShreeram Akilesh
Published in: Journal of the American Society of Nephrology : JASN (2022)
Our results demonstrate a causal role for serum proteins in tubular injury and identify regulatory mechanisms and novel pathways for intervention.
Keyphrases
  • endothelial cells
  • transcription factor
  • randomized controlled trial
  • quality improvement
  • induced pluripotent stem cells
  • high glucose
  • protein protein
  • pluripotent stem cells
  • binding protein
  • small molecule