Tumor-Specific Major Histocompatibility-II Expression Predicts Benefit to Anti-PD-1/L1 Therapy in Patients With HER2-Negative Primary Breast Cancer.
Paula I Gonzalez EricssonJulia D WulfkhuleRosa I GallagherXiaopeng SunMargaret L AxelrodQuanhu ShenNa LuoHenry L GómezVioleta SanchezMelinda E SandersLajos PusztaiEmanuel PetricoinKim R M BlenmanJustin M Balkonull nullPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Tumor-specific MHC-II has a strong candidacy as a specific biomarker of anti-PD-1/L1 immunotherapy benefit when added to standard NAC in HER2-negative breast cancer. Combined with previous studies in melanoma, MHC-II has the potential to be a pan-cancer biomarker. Validation is warranted in existing and future phase II/III clinical trials in this setting.