iNetModels 2.0: an interactive visualization and database of multi-omics data.
Muhammad ArifCheng ZhangXiangyu LiCem GüngörBuğra ÇakmakMetin ArslantürkAbdellah TebaniBerkay ÖzcanOğuzhan SubaşWenyu ZhouBrian PieningHasan TurkezLinn FagerbergNathan PriceLeroy HoodMichael SnyderJens B NielsenMathias UhlenAdil MardingluPublished in: Nucleic acids research (2021)
It is essential to reveal the associations between various omics data for a comprehensive understanding of the altered biological process in human wellness and disease. To date, very few studies have focused on collecting and exhibiting multi-omics associations in a single database. Here, we present iNetModels, an interactive database and visualization platform of Multi-Omics Biological Networks (MOBNs). This platform describes the associations between the clinical chemistry, anthropometric parameters, plasma proteomics, plasma metabolomics, as well as metagenomics for oral and gut microbiome obtained from the same individuals. Moreover, iNetModels includes tissue- and cancer-specific Gene Co-expression Networks (GCNs) for exploring the connections between the specific genes. This platform allows the user to interactively explore a single feature's association with other omics data and customize its particular context (e.g. male/female specific). The users can also register their data for sharing and visualization of the MOBNs and GCNs. Moreover, iNetModels allows users who do not have a bioinformatics background to facilitate human wellness and disease research. iNetModels can be accessed freely at https://inetmodels.com without any limitation.
Keyphrases
- adverse drug
- electronic health record
- single cell
- endothelial cells
- high throughput
- big data
- genome wide
- mass spectrometry
- machine learning
- poor prognosis
- squamous cell carcinoma
- body composition
- induced pluripotent stem cells
- healthcare
- social media
- data analysis
- health information
- long non coding rna
- young adults
- dna methylation
- pluripotent stem cells
- electron microscopy