Circulating Malondialdehyde Concentrations in Obstructive Sleep Apnea (OSA): A Systematic Review and Meta-Analysis with Meta-Regression.
Maria Carmina PauElisabetta ZinelluSara S FoisBarbara PirasGianfranco PintusCiriaco CarruArduino Aleksander MangoniAlessandro Giuseppe FoisAngelo ZinelluPietro PirinaPublished in: Antioxidants (Basel, Switzerland) (2021)
Oxidative stress induced by nocturnal intermittent hypoxia plays a significant pathophysiological role in obstructive sleep apnea (OSA). Malondialdehyde (MDA), one of the most commonly investigated markers of lipid peroxidation, might assist with the monitoring of oxidative balance in OSA. We conducted a systematic review and meta-analysis to evaluate the differences in circulating MDA concentrations between patients with OSA and non-OSA controls. A systematic search was conducted in the electronic databases Pubmed, Web of Science, Scopus and Google Scholar from inception to December 2020 by using the following terms: "malondialdehyde" or "MDA"; and "Obstructive Sleep Apnea Syndrome", "OSAS" or "OSA". We identified 26 studies in 1223 OSA patients and 716 controls. The pooled MDA concentrations were significantly higher in patients with OSA (standardized mean difference (SMD) 1.43 μmol/L, 95% confidence interval (CI) 1.03 to 1.83 μmol/L, p < 0.001). There was extreme heterogeneity between the studies (I2 = 92.3%, p < 0.001). In meta-regression analysis, the SMD was significantly associated with age, the assay type used and publication year. In our meta-analysis, MDA concentrations were significantly higher in OSA patients than in controls. This finding suggests that MDA, which is a marker of lipid peroxidation, is involved in the pathogenesis of OSA and provides insights for future studies investigating its potential clinical use.
Keyphrases
- obstructive sleep apnea
- positive airway pressure
- breast cancer cells
- end stage renal disease
- sleep apnea
- chronic kidney disease
- systematic review
- ejection fraction
- oxidative stress
- newly diagnosed
- case control
- cell cycle arrest
- peritoneal dialysis
- public health
- depressive symptoms
- randomized controlled trial
- dna damage
- cell death
- machine learning
- cell proliferation
- big data
- high intensity
- mass spectrometry
- physical activity
- meta analyses
- heat stress
- signaling pathway
- case report
- endoplasmic reticulum stress
- fatty acid
- deep learning
- current status