High concordance between hippocampal transcriptome of the mouse intra-amygdala kainic acid model and human temporal lobe epilepsy.
Giorgia ConteAlberto ParrasMariana AlvesIvana OllàLaura De Diego-GarciaEdward BeamerRazi AlalqamAlejandro OcampoRaúl MendezDavid C HenshallJosé J LucasTobias Engel Ayer BotrelPublished in: Epilepsia (2020)
Our findings suggest the intra-amygdala kainic acid model faithfully replicates key molecular features of human drug-resistant TLE and provides potential rational target approaches for disease-modification through new insights into the unique and shared gene expression landscape in experimental epilepsy.
Keyphrases
- temporal lobe epilepsy
- drug resistant
- gene expression
- endothelial cells
- multidrug resistant
- induced pluripotent stem cells
- acinetobacter baumannii
- pluripotent stem cells
- dna methylation
- single cell
- genome wide
- functional connectivity
- pseudomonas aeruginosa
- single molecule
- brain injury
- subarachnoid hemorrhage
- cerebral ischemia