Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes.
Roman KotłowskiPublished in: Life (Basel, Switzerland) (2021)
The impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration ( p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with intracellular pathogenic E. coli strain UM146 versus non-pathogenic E. coli Nissle 1917. Among the features influenced by the UM146 bacterial strain were visual learning, response to the presence of morphine, response to hypoxia, behavioral fear response and cognitive functions.
Keyphrases
- escherichia coli
- endothelial cells
- genome wide
- poor prognosis
- klebsiella pneumoniae
- induced pluripotent stem cells
- dna methylation
- pluripotent stem cells
- binding protein
- biofilm formation
- prefrontal cortex
- emergency department
- long non coding rna
- multidrug resistant
- cystic fibrosis
- copy number
- staphylococcus aureus
- nucleic acid
- adverse drug