Endogenous Antiangiogenic Factors in Chronic Kidney Disease: Potential Biomarkers of Progression.
Katsuyuki TanabeYasufumi SatoJun WadaPublished in: International journal of molecular sciences (2018)
Chronic kidney disease (CKD) is a major global health problem. Unless intensive intervention is initiated, some patients can rapidly progress to end-stage kidney disease. However, it is often difficult to predict renal outcomes using conventional laboratory tests in individuals with CKD. Therefore, many researchers have been searching for novel biomarkers to predict the progression of CKD. Angiogenesis is involved in physiological and pathological processes in the kidney and is regulated by the balance between a proangiogenic factor, vascular endothelial growth factor (VEGF)-A, and various endogenous antiangiogenic factors. In recent reports using genetically engineered mice, the roles of these antiangiogenic factors in the pathogenesis of kidney disease have become increasingly clear. In addition, recent clinical studies have demonstrated associations between circulating levels of antiangiogenic factors and renal dysfunction in CKD patients. In this review, we summarize recent advances in the study of representative endogenous antiangiogenic factors, including soluble fms-related tyrosine kinase 1, soluble endoglin, pigment epithelium-derived factor, VEGF-A165b, endostatin, and vasohibin-1, in associations with kidney diseases and discuss their predictive potentials as biomarkers of progression of CKD.
Keyphrases
- chronic kidney disease
- end stage renal disease
- vascular endothelial growth factor
- tyrosine kinase
- endothelial cells
- ejection fraction
- newly diagnosed
- randomized controlled trial
- peritoneal dialysis
- public health
- oxidative stress
- prognostic factors
- adipose tissue
- patient reported outcomes
- cross sectional
- patient reported
- drug induced
- high fat diet induced