METTL3-Mediated lncRNA m6A Modification in the Osteogenic Differentiation of Human Adipose-Derived Stem Cells Induced by NEL-Like 1 Protein.

Yidan SongYihua PanMengsong WuWentian SunLiangyu LuoZhihe ZhaoJun Liu

Published in: Stem cell reviews and reports (2021)

This study shows, for the first time, that METTL3 can activate the MAPK signaling pathway by regulating the m6A modification and expression of a lncRNA, thereby enhancing the osteogenic differentiation of hASCs.

Keyphrases

signaling pathway
pi k akt
endothelial cells
long non coding rna
poor prognosis
epithelial mesenchymal transition
oxidative stress
long noncoding rna
induced pluripotent stem cells
binding protein
pluripotent stem cells
endoplasmic reticulum stress