Immune Profiling Mass Cytometry Assay Harmonization: Multicenter Experience from CIMAC-CIDC.

Bita SahafMina PichavantBrian H LeeCaroline Duault Emily M Thrash Melanie DavilaNicolas FernandezKaren MillerchipSalah-Eddine Bentebibel Cara L HaymakerNatalia SigalDiane M Del ValleSrinika RanasingheSarah FayleBeatriz Sanchez-EspiridionJianhua Zhang Chantale Bernatchez Catherine J WuIgnacio I WistubaSeunghee Kim-SchulzeSacha Gnjatic Sean C BendallMinkyung SongMagdalena ThurinJiun-Kae Jack LeeHolden T MaeckerAdeeb Rahman

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

These results establish the ability to reproduce CyTOF data across sites in multicenter clinical trials, and also highlight the importance of quality control procedures, such as the use of spike-in control samples, for tracking variability in this assay.

Keyphrases

quality control
clinical trial
high throughput
single cell
double blind
cross sectional
electronic health record
big data
randomized controlled trial
phase ii
machine learning
open label
deep learning