Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder.

Clara SnijdersAdam X MaihoferAndrew RatanatharathornDewleen G BakerMarco P BoksElbert GeuzeSonia JainRonald C KesslerEhsan PishvaVictoria B RisbroughMurray B SteinRobert J UrsanoEric VermettenChristiaan H Vinkersnull nullAlicia K SmithMonica UddinBart P F RuttenCaroline M Nievergelt

Published in: Clinical epigenetics (2020)

This study suggests that the development of combat-related PTSD is associated with distinct methylation patterns in several genomic positions and regions. Our most prominent findings suggest the involvement of the immune system through the HLA region and HEXDC, and MAD1L1 which was previously associated with PTSD.

Keyphrases

dna methylation
posttraumatic stress disorder
genome wide
social support
copy number
depressive symptoms
gene expression
cross sectional
single cell