Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies.

Javier Glez-VazArantza AzpilikuetaIrene OliveraAssunta CirellaAlvaro TeijeiraMaria C OchoaMaite Alvarez Iñaki EgurenCarlos Luri-ReyMaria E Rodriguez-RuizXinxin NieLieping ChenSonia GuedanMiguel F SanamedJose Luis Perez GraciaIgnacio Melero Bermejo

Published in: Journal for immunotherapy of cancer (2022)

sCD137 in plasma and CD137 surface expression can be used as quantitative parameters dynamically reflecting therapeutic costimulatory activity elicited by agonist CD137-targeted agents.

Keyphrases

nk cells
poor prognosis

high resolution

mass spectrometry

binding protein