Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition.
Brent J GuppyKirk James McManusPublished in: Cellular oncology (Dordrecht) (2017)
Collectively, our data indicate that RNF20 and PARP1 are synthetic lethal interactors, suggesting that cancers with diminished RNF20 expression and/or function may be susceptible to PARP1 inhibitors.