Melatonin for preventing primary headache: A systematic review.

Rafael Leite Pacheco Carolina de Oliveira Cruz LatorracaAnderson Adriano Leal Freitas da CostaAna Luiza Cabrera MartimbiancoDaniela Vianna PachitoRachel Riera

Published in: International journal of clinical practice (2018)

This review found that so far there are few clinical trials, with poor methodological quality about melatonin for primary headaches. The available evidence is not sufficient to support the use of melatonin in clinical practice for this population. Further research is still necessary for assess its effects (benefits and harms) for primary headaches patients. Number of Protocol registration in PROSPERO database: CRD42017067105 (available at https://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42017067105) .

Keyphrases

clinical trial
end stage renal disease
clinical practice
ejection fraction
randomized controlled trial
chronic kidney disease
newly diagnosed
peritoneal dialysis
emergency department
cross sectional
quality improvement
patient reported outcomes
double blind
study protocol
open label