Oral regimen for high dose methotrexate urine alkalinization: a systematic review and meta-analysis.

Romina Kaveh-Ahangaran Mohammad Abdollahi Mohammad Vaezi Amir KasaeianZhalleh BahlouliGhasem Janbabaee Amirmahdi Mojtahedzadeh Mojtaba Mojtahedzadeh Shirin Djalalinia Bita Shahrami

Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2024)

An oral bicarbonate regimen is a safe and effective way to alkalize HDMTX urine, providing a viable and cost-effective alternative to IV protocols. Further prospective multicenter studies are necessary. Systematic review registration identifier: CRD42023379666.

Keyphrases

high dose
systematic review
low dose
stem cell transplantation
meta analyses
randomized controlled trial
clinical trial
cross sectional