Login / Signup

Administration time effect of dietary proanthocyanidins on the metabolome of Fischer 344 rats is sex- and diet-dependent.

Verónica Arreaza-GilHéctor Palacios-JordanMaría Del Mar RomeroCristina Torres-FuentesMiguel A RodríguezXavier RemesarJosé Antonio Fernández-LópezAnna Arola-Arnal
Published in: Food & function (2023)
Proanthocyanidins (PAs) are one of the most commonly ingested polyphenols in the human diet, with a wide range of beneficial health effects. Remarkably, PAs have been reported to influence core and peripheral clock genes expression, and their effects may change in a time-of-day dependent manner. Therefore, the aim of this study was to investigate whether the capacity of PAs to modulate the metabolome is conditioned by the time-of-day in which these compounds are consumed in a diet- and sex-dependent manner. To do this, a grape seed proanthocyanidin extract (GSPE) was administered to female and male Fischer 344 rats at ZT0 (in the morning) and ZT12 (at night) and the GSPE administration time effect was evaluated on clock genes expression, melatonin hormone and serum metabolite levels in a healthy and obesogenic context. The results showed an administration time effect of GSPE on the metabolome in a sex and diet-dependent manner. Specifically, there was an effect on amino acid, lipid and cholate metabolite levels that correlated with the central clock genes expression. Therefore, this study shows a strong influence of sex and diet on the PAs effects on the metabolome, modulated in turn by the time-of-day.
Keyphrases
  • weight loss
  • physical activity
  • poor prognosis
  • genome wide
  • endothelial cells
  • amino acid
  • binding protein
  • genome wide identification
  • oxidative stress
  • bioinformatics analysis
  • depressive symptoms
  • genome wide analysis