CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma.
Anke SchlüterPatrick WellerOliver KanaanIvonne NelLukas HeusgenBenedikt HöingPia HaßkampSebastian ZanderMagis MandapathilNina DominasJudith ArnoldsBoris A StuckStephan LangAgnes BankfalviSven BrandauPublished in: BMC cancer (2018)
Only in the early stage subgroup a high expression of angiogenic biomarkers was associated with reduced survival and an increased rate of recurrence. Thus, biomarkers of angiogenesis may be useful to identify high risk patients specifically in early stage LSCC.
Keyphrases
- early stage
- squamous cell carcinoma
- end stage renal disease
- sentinel lymph node
- vascular endothelial growth factor
- endothelial cells
- newly diagnosed
- chronic kidney disease
- ejection fraction
- poor prognosis
- free survival
- randomized controlled trial
- peritoneal dialysis
- patient reported outcomes
- lymph node metastasis
- radiation therapy
- long non coding rna
- lymph node
- binding protein
- neoadjuvant chemotherapy
- phase iii
- rectal cancer