Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data.
Franziska KluweRobin MicheletWilhelm HuisingaMarkus ZeitlingerGerd MikusCharlotte KloftPublished in: Clinical pharmacokinetics (2023)
Our results highlight the potential clinical impact of MIPD for voriconazole and indicate the need for a comprehensive (pre-)clinical database as basis for model development and careful external model evaluation for compounds with complex PK before their successful use in MIPD.