Myoglobin Inhibits Breast Cancer Cell Fatty Acid Oxidation and Migration via Heme-dependent Oxidant Production and Not Fatty Acid Binding.

Aaron R JohnsonKrithika RaoBob B ZhangSteven MulletEric S Goetzman Stacy Gelhaus Wendell Jesús Tejero Sruti Shiva

Published in: bioRxiv : the preprint server for biology (2024)

Myoglobin (Mb) expression in MDA-MB-231 breast cancer cells slows migration.Mb expression decreases mitochondrial respiration and fatty acid oxidation.Mb-dependent fatty acid binding does not regulate cell migration or respiration.Mb-dependent oxidant generation decreases mitochondrial metabolism and migration.Mb-derived oxidants dysregulate migratory gene expression.

Keyphrases

fatty acid
gene expression
breast cancer cells
cell migration
poor prognosis
oxidative stress
binding protein
dna methylation
hydrogen peroxide
dna binding
signaling pathway
long non coding rna
cell death
visible light