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The effect of SSRIs on fear learning: a systematic review and meta-analysis.

Elise J HeesbeenElisabeth Y BijlsmaP Monika VerdouwCaspar van LissaCarlijn HooijmansLucianne Groenink
Published in: Psychopharmacology (2023)
This review suggests that the efficacy of SSRIs may be related to their effects on contextual fear expression and extinction to cue, rather than fear acquisition. However, these effects of SSRIs may be due to a more general inhibition of fear-related emotions. Therefore, additional meta-analyses on the effects of SSRIs on unconditioned fear responses may provide further insight into the actions of SSRIs.
Keyphrases
  • prefrontal cortex
  • meta analyses
  • systematic review
  • poor prognosis
  • randomized controlled trial
  • long non coding rna